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This oxPPP increase can be phenocopied by treating cells with the carbon monoxide-producing molecule tricarbonylchloro(glycinatro)ruthenium, with release of carbon monoxide by HMOX1 seeming to promote PPP activity, although the biochemical mechanism remains unknown 99

doi: 10.1189/jlb.3MR0316-106R 205 MaesMMihaylovaILeunisJC

Similarly, in GV-stage mouse oocytes exposed to vitrification, there is an accumulation of mitochondrial ROS and an elevated rate of apoptosis, both of which are closely associated with mitochondrial dysfunction (47)

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